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Jun
Urens leaves CULHA in Wistar rats. In acute toxicity study CULHA was administered at a single oral dose of 2000 mgkg body weight.
Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles Author.
Acute toxicity studies in rats. Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles Data generated using standardized testing protocols for toxicity studies generally provide reproducible and reliable results for establishing safe levels and formulating risk assessments. The acute oral LD 50 in male Sprague-Dawley S-D rats was estimated in the present study to be 82 gkg of body weight bw. Deaths appeared to be due to CNS depression and respiratory failure.
In an acutesubacute experiment male S-D rats were given 0 1 2 4 or 8 g DCEkg in corn oil by gavage for 1 5 or 10 consecutive days. For acute oral toxicity testing a sighting study was conducted on female rats in a sequential manner to allow selection of the appropriate starting dose for the main study. In acute toxicity the dosage was 2000 mgkg body weight for four female rats.
In the acute toxicity study dose estimated was LD50 in the range of 2000-5000mgkg signs of mortality and toxicity on female rats were observed for 14 days after single doses of 2000 and 5000mgkg. In the sub-acute study female and male rats age 10 weeks were supplemented at doses of 250 500 and 1000mgkg for 28 days. The purpose of this study was to evaluate the potential toxicity of seabuckthorn oil by an acute oral toxicity study in mice and a 90-day repeated oral toxicity study in rats.
No mortality or signs of toxicity was observed in mice treated with 20 mLkg body weight seabuckthorn oil in the acute toxicity study. In the subchronic toxicity study 80 Sprague-Dawley rats 10 animals per sex per treatment group were. Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles Author.
Warheit DB Brown SC Donner EM. Food and chemical toxicology 2015 v84 pp. In the oral acute toxicity study female Wistar rats were treated with doses of 10 100 1000 1600 2900 and 5000 mg kg of the Juglans regia septum of methanol extract JRSME and were monitored for 14 days.
In subchronic study JRSME was administered by gavage at dose of 1000 mgkg daily in Wistar rats for 28 days. This study was carried out to investigate the acute oral toxicity and histopathological changes of cypermethrin in albino rats. According to Finneys probit analysis method at 48 h LD 50 value of cypermethrin in rats was found to be 205 mgkg bw by gavage.
Behavioral changes in rats after oral administration of cypermethrin showed motor signs. The results of acute toxicity study showed that the LD50 value of OR is higher than 200gkg BW in mice. Death and abnormal clinical symptoms were not found during the period of experiment.
In sub-acute toxicity we found that the no-observed-adverse-effect levels NOAEL of OR in rats is up to 700gkg BW. In the first acute and subacute toxicity study male Sprague-Dawley rats of 300-350 g were gavaged with 0 20 40 or 80 mg CCl4kg once daily for 5 consecutive. This investigation was conducted to characterize the acute subacute and subchronic toxic potency of ingested carbon tetrachloride CCl4.
Acute Toxicity Studies in Rabbits and Rats with Hexabromocyclododecane with Attachments. Hexabromocyclododecane was assessed for primary eye irritation with New Zealand White rabbits 3sex administered 100 mg of test material in the conjunctival sac of the right eye. This study was carried out to investigate the acute oral toxicity andhistopathological changes of cypermethrin in albino rats.
According to Finneys probit analysismethod at 48 h LD50 value of cypermethrin in rats was found to be 205 mgkg bw by gavageBehavioral changes in rats after oral administration of cypermethrin showed motor signs. In acute oral toxicity study NK was administered at 2000mgkg bwt po and animals were observed for toxic signs at 0 05 1 4 24 h and for next 14 days. Gross pathology was performed at the end of the study.
In repeated dose the 28- day oral toxicity study NK was administered at 300 600 and 900 mgkg bwtpoday. Sub-acute toxicity of ginger extract was studied by feeding the extract at 100 500 and 1000 mgkg daily to rats as per OECD guidelines 407. The total gingerols content in the purified viscous extract was 36-43.
The finished formulation of ginger extract used for the toxicity studies had 8 total gingerols. Current investigation was to assess the potential toxicity of the hydroalcoholic extract of C. Urens leaves CULHA in Wistar rats.
In acute toxicity study CULHA was administered at a single oral dose of 2000 mgkg body weight. In subacute toxicity study CULHA was administered once a day at three dose levels of 100 200 and 400 mg. The aqueous extract of raw areca nut extract was evaluated for its acute oral toxicity study in rats.
Healthy male and female Wistar albino rats aged between 10 to 12 weeks and weighing 190 to 210 g adult were selected. The animals were fasted overnight and raw areca nut extract in graded doses. Repeated Dose Toxicity Studies Study design Rodents.
8-10 per dose per sex 3 dosages Other approaches. More dosages but smaller groups for more precise determination of sensitivity more precise dose-response relationshipsnot usual with pharmaceuticals Disclaimer. Exceptions are possible if justifiable.